The BBC's Ben Wright asks if Johnson and Harries accept that infection rates will go up now that children in England are back in the classroom - and what would be an acceptable level.
The PM says a risk of increased transmission now that schools are back is "inevitable".
But he adds that immunity has "bedded in" for millions of people who have now had their first dose of the Covid vaccine, which means it's safe to continue with the reopening plans.
As we approach the next steps of lockdown easing we must be "very, very cautious," the PM warns.
Harries adds that education is of public health importance "just as much as Covid is" so the UK should press on with getting children back to school.
She adds that it will be difficult to tell what impact a return to schools has to the numbers, because social interaction will also increase as the roadmap continues.
While the news conference is about the continuing pandemic, the PM is asked about the big story of the day - the Duke and Duchess of Sussex's interview with Oprah Winfrey.
"I've always had the highest admiration for the Queen and the unifying role that she plays in our country and across the Commonwealth," he says.
He says he's spent "a long time" not commenting on Royal Family matters and doesn't plan to make that change.
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2021-03-08 16:14:59Z
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