The NHS has written to local health organisations warning of a "significant reduction in weekly supply" of coronavirus vaccines from the week beginning 29 March for a month.
It says there has been a "reduction in national inbound vaccines supply".
It also says organisations should "ensure no further appointments are uploaded to the national booking system or local booking system" in April.
The BBC understands no one who has booked a vaccine should lose a slot.
Asked about the letter, Health Secretary Matt Hancock said "vaccine supply is always lumpy", and added that the NHS regularly sent out "technical letters" explaining the "ups and downs" of supply.
The letter says "over this next period it is vital" that health organisations focus on vaccinating those in the one to nine groups who are most vulnerable to coronavirus.
It advises vaccination services to work with local authorities, voluntary community and faith organisations "to put in place reserve lists" of people eligible for the vaccine, as well as targeting areas of lower uptake.
The NHS says vaccination centres and community pharmacy-led services should close unfilled bookings from the week commencing 29 March.
Earlier, it was announced that almost half of British adults have received their first dose of a coronavirus vaccine.
The Department of Health said 25 million people had received their first dose, while 1.7 million had been given their second dose.
Mr Hancock said that the nation was "ahead of schedule" to offer a first dose to all over-50s by 15 April.
All adults in the UK are expected to be offered their first dose of a coronavirus vaccine by the end of July.
Speaking at a press conference, Mary Ramsay, the head of immunisation at Public Health England, said "every day we vaccinate more people we are preventing more deaths".
BBC politics correspondent Jonathan Blake said the hold-up would have an impact on the momentum of the vaccine rollout and possibly the government's targets.
https://news.google.com/__i/rss/rd/articles/CBMiL2h0dHBzOi8vd3d3LmJiYy5jby51ay9uZXdzL3VrLXBvbGl0aWNzLTU2NDM1NTQ50gEzaHR0cHM6Ly93d3cuYmJjLmNvLnVrL25ld3MvYW1wL3VrLXBvbGl0aWNzLTU2NDM1NTQ5?oc=5
2021-03-17 17:06:43Z
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