Everybody has to "play their part" to meet the dates for England's lockdown to be eased, Health Secretary Matt Hancock has warned.
It comes after Boris Johnson outlined his four-step strategy that could see restrictions lifted by 21 June - if strict conditions are met.
The PM faces criticism from some of his own MPs who believe the pace of change is too slow.
Scotland First Minister Nicola Sturgeon will reveal her own plan later.
She has said Scotland will return to a tiered system when measures are eased, meaning different parts of the country could be under different rules.
Mr Hancock told BBC Breakfast: "This is on all of us. It depends how all of us respond. Right now, we need to keep doing what we're doing and staying at home to make sure we can keep levels rates coming down while we roll the vaccine out."
It is "vital" that "everybody plays their part" as they have been doing during lockdown, he added.
Mr Hancock said: "This isn't just on us in government - although we will play our part - it's on everyone to act together to keep doing their bit to make sure that we hit these dates and get out of this as soon as we possibly can, safely."
But he said it is too soon to say when social distancing measures, like the two metre rule, will be scrapped. It is also not known when international travel will be able to resume.
Meanwhile, the government wants to determine whether offering "Covid status" certificates, which could be used by people to demonstrate they had received a vaccine or a negative coronavirus test, could help venues open again.
The prime minister said his plan offers the best chance to avoid another lockdown.
In the first step of his roadmap, all pupils in England's schools are expected to return to class from 8 March, with mass testing and wider use of face masks in secondary schools.
There will be a further easing on 29 March, with groups of up to six people or two households allowed to gather in parks and gardens.
Shops, hairdressers, gyms and outdoor hospitality, as well as self-contained holiday accommodation, could reopen on 12 April. A review of international leisure travel restrictions could also be announced.
From 17 May, two households or a group of six may be able to meet indoors in a pub or other hospitality venue such as restaurants.
Cinemas, museums, hotels, performances and sporting events will also reopen, with up to 30 people able to attend weddings, receptions, funerals and wakes.
The final step from 21 June will potentially see all legal limits on social contact removed, with the final closed sectors of the economy reopened - such as nightclubs.
Progressing along the schedule will depend on four tests: the success of the vaccine rollout, evidence of vaccine efficacy, an assessment of new variants, and keeping infection rates below a level that could put unsustainable pressure on the NHS.
There will be a gap of at least five weeks between each of the plan's subsequent steps to allow for the impact of changes on infection rates and hospital admissions to be assessed.
Mr Johnson told a Downing Street news conference the coming spring and summer would be "seasons of hope, looking and feeling incomparably better for us all".
He said he could not guarantee his plan would be irreversible "but the intention is that it should be".
On the issue of vaccine certificates, Mr Johnson acknowledged there were "clearly some quite complex issues, some ethical issues" as vaccination isn't compulsory but told a meeting of his own MPs on Monday evening that "a debate had to be had".
Some Tory MPs unhappy
The prime minister addressed the 1922 backbench committee of Conservative MPs on Monday night.
He faced criticism of what some saw as slow progress in removing restrictions.
One participant suggested he was talking "gibberish" when he compared his route map to a motorway journey.
Another said the PM had been "rattled".
What annoyed some MPs was an apparent lack of flexibility in the plan with restrictions not being lifted "before" certain dates.
He was urged to keep open the possibility of bringing these dates forward if data allowed but there was "no backtracking" on the five-week wait between steps.
MPs will vote on the roadmap in late March.
Labour leader Sir Keir Starmer welcomed the plan but said certainty was needed over the future of the government furlough scheme for both businesses and workers.
Labour shadow chancellor Anneliese Dodds told BBC Radio 4's Today programme that without clarity on business support - like the VAT reduction and the business rates holiday - "many businesses are simply throwing in the towel now and we cannot afford that in the UK when we've already had record redundancies".
Conservative MP Steve Baker, deputy chair of the Covid Recovery Group of Tory lockdown-sceptics, said the "pace of change will be a hammer blow" to industries such as aviation, hospitality and the arts.
However, UK chief scientific adviser Sir Patrick Vallance said it was "very important" to leave a gap of five weeks between the changes in the roadmap to avoid "flying blind".
Sir Patrick also said "baseline" measures - such as face coverings in certain situations, hand washing, and self-isolation - may be necessary next winter.
The devolved nations have the power to set their own restrictions.
In Wales, First Minister Mark Drakeford has said he hopes the "stay-at-home" requirement could end within three weeks, with some non-essential shops and hairdressers possibly reopening at the same time.
Northern Ireland's First Minister Arlene Foster wants its executive to discuss the reopening date for schools following Mr Johnson's announcement in England.
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More than 17.7 million people across the UK have now received at least one vaccine dose, according to latest government figures.
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2021-02-23 07:36:23Z
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